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Table 4 Highly transcribed membrane channels in proximal tubule

From: Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

Gene Alias TPM Description PT rank CP rank
KCNJ16 Kir5.1 235 Inwardly rectifying K+ channel 5.1 1 N/A
KCNJ1 Kir1.1 89 Inwardly rectifying K+ channel 1.1 2 N/A
AQP1 AQP1 48 Aquaporin 1 3 2
TRPV1 TRPV1 15 Transient receptor potential vanilloid channel 1 4 N/A
GJB2 Cx26 13 Connexin 26 5 20
AQP3 AQP3 10 Aquaporin 3 6 N/A
AQP7 AQP7 9 Aquaporin 7 7 N/A
TRPM7 TRPM7 9 Transient receptor potential melastatin channel 7 8 10
GABRP GABARπ 9 GABA(A) receptor π 9 N/A
MCOLN1 TRPML1 8 Transient receptor potential mucolipin channel 1 10 7
MCOLN3 TRPML3 7 Transient receptor potential mucolipin channel 3 11 N/A
CLCN4 ClC-4 4 Voltage-gated Cl channel 4 12 18
CFTR CFTR 4 Cystic fibrosis transmembrane conductance regulator 13 N/A
CLCNKA ClCK1 3 Voltage-gated Cl channel 14 N/A
GJB1 Cx32 3 Connexin 32 15 N/A
KCNJ15 Kir4.2 2 Inwardly rectifying K+ channel 4.2 16 85
CHRNB1 ACHB 2 Acetylcholine receptor β 17 47
PANX2 Panx2 2 Pannexin 2 18 40
P2RX4 P2X4 2 Purinergic receptor X4 19 28
GJA1 Cx43 2 Connexin 43 20 27
  1. RNAseq analysis revealing the 20 highest expressed genes encoding plasma membrane channels in proximal tubule. TPM: transcripts per million; PT rank: each gene’s rank in the proximal tubule sample; CP rank: each gene’s rank in the choroid plexus sample, N/A: not applicable if the genes is transcribed below the applied cut-off of 0.5 TPM