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Table 4 Highly transcribed membrane channels in proximal tubule

From: Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

Gene

Alias

TPM

Description

PT rank

CP rank

KCNJ16

Kir5.1

235

Inwardly rectifying K+ channel 5.1

1

N/A

KCNJ1

Kir1.1

89

Inwardly rectifying K+ channel 1.1

2

N/A

AQP1

AQP1

48

Aquaporin 1

3

2

TRPV1

TRPV1

15

Transient receptor potential vanilloid channel 1

4

N/A

GJB2

Cx26

13

Connexin 26

5

20

AQP3

AQP3

10

Aquaporin 3

6

N/A

AQP7

AQP7

9

Aquaporin 7

7

N/A

TRPM7

TRPM7

9

Transient receptor potential melastatin channel 7

8

10

GABRP

GABARÏ€

9

GABA(A) receptor π

9

N/A

MCOLN1

TRPML1

8

Transient receptor potential mucolipin channel 1

10

7

MCOLN3

TRPML3

7

Transient receptor potential mucolipin channel 3

11

N/A

CLCN4

ClC-4

4

Voltage-gated Cl− channel 4

12

18

CFTR

CFTR

4

Cystic fibrosis transmembrane conductance regulator

13

N/A

CLCNKA

ClCK1

3

Voltage-gated Cl− channel

14

N/A

GJB1

Cx32

3

Connexin 32

15

N/A

KCNJ15

Kir4.2

2

Inwardly rectifying K+ channel 4.2

16

85

CHRNB1

ACHB

2

Acetylcholine receptor β

17

47

PANX2

Panx2

2

Pannexin 2

18

40

P2RX4

P2X4

2

Purinergic receptor X4

19

28

GJA1

Cx43

2

Connexin 43

20

27

  1. RNAseq analysis revealing the 20 highest expressed genes encoding plasma membrane channels in proximal tubule. TPM: transcripts per million; PT rank: each gene’s rank in the proximal tubule sample; CP rank: each gene’s rank in the choroid plexus sample, N/A: not applicable if the genes is transcribed below the applied cut-off of 0.5 TPM