Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

Table 3 Highly transcribed transporters and pumps in proximal tubule

Gene	Alias	TPM	Description	PT Rank	CP Rank
SLC7A13	XAT2	7344	Na⁺-independent aspartate/glutamate transporter	1	N/A
SLC3A1	NBAT	3113	Neutral and basic amino acid transporter	2	98
SLC16A4	MCT5	993	Monocarboxylate transporter 5	3	N/A
SLC13A1	NAS1	384	Na⁺, SO₄²⁻ transporter 1	4	N/A
FXYD2	FXYD2	359	Na⁺/K⁺ ATPase γ2	5	N/A
PDZD11	PDZD11	279	Plasma membrane Ca²⁺ ATPase-interacting single-PDZ Protein	6	30
ABCG2	BCRP	164	ATP binding cassette transporter G2	7	209
SLC17A3	NPT4	148	Na⁺, PO₄³⁻ transporter 4	8	N/A
SLC5A12	SMCT2	147	Na⁺-coupled monocarboxylate transporter 2	9	N/A
SLC31A1	CTR1	136	Cu²⁺ transporter 1	10	8
SLC51B	OSTB	131	Organic solute transporter β	11	N/A
ATP1B1	NKA.β1	98	Na⁺/K⁺-ATPase β1	12	2
MAGT1	MAGT1	72	Mg²⁺ transporter protein 1	13	58
SLC34A1	NPT2	67	Na⁺, PO₄³⁻ transporter 2	14	N/A
SLC16A12	MCT12	45	Monocarboxylate transporter 12	15	42
SLC22A6	OAT1	29	Organic anion transporter 1	16	N/A
SLC22A2	OCT2	25	Organic cation transporter 2	17	N/A
TMEM30A	TMEM30A	24	P4-ATPase flippase β subunit	18	18
SLC15A2	PEPT2	22	Peptide transporter 2	19	87
SLC5A2	SGLT2	22	Na⁺, glucose cotransporter 2	20	137

RNAseq analysis revealing the 20 highest expressed genes encoding plasma membrane transporters and pumps in proximal tubule. TPM: transcripts per million; PT rank: each gene’s rank in the proximal tubule sample; CP rank: each gene’s rank in the choroid plexus sample; N/A: not applicable if the genes is transcribed below the applied cut-off of 0.5 TPM

ISSN: 2045-8118