Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

Table 1 Highly transcribed transporters and pumps in choroid plexus

Gene	Alias	TPM	Description	Rank	FACS rank	Female rank
SLC22A17	BOCT	2396	Brain-specific organic cation transporter	1	1	1
ATP1B1	NKAβ	1553	Na⁺/K⁺-ATPase β1	2	2	2
FXYD1	FXYD1	1076	Na⁺/K⁺-ATPase γ1	3	3	3
SLC4A5	NBCE2	881	Na⁺,HCO₃⁻ cotransporter	4	7	4
SLC4A2	AE2	638	Cl⁻/HCO₃⁻ exchanger	5	5	5
SLC13A4	SUT1	627	Na⁺,SO₄²⁻ cotransporter	6	6	7
ATP1A1	NKA.α1	623	Na⁺/K⁺ ATPase α1	7	4	6
SLC31A1	CTR1	469	Cu²⁺ transporter 1	8	9	8
ATP2B3	PMCA3	396	Plasma membrane Ca²⁺ ATPase	9	15	11
SLC16A2	MCT8	380	Monocarboxylate transporter 8	10	13	9
SLC4A10	NCBE	325	Na⁺, HCO₃⁻ cotransporter	11	26	12
SLCO1C1	BSAT1	301	BBB-specific anion transporter 1	12	12	13
SLC38A3	SNAT3	298	Na⁺-coupled neutral amino acid transporter 3	13	8	10
SLC12A2	NKCC1	268	Na⁺, K⁺, 2Cl⁻ cotransporter	14	17	14
ATP1B2	NKA.β2	248	Na⁺/K⁺ ATPase β2	15	18	17
ATP11A	ATP11A	242	Phospholipid-transporting ATPase	16	23	19
ATP1B3	NKA.β3	236	Na⁺/K⁺ ATPase β3	17	10	15
TMEM30A	TMEM30A	229	P4-ATPase flippase β subunit	18	21	16
SLC12A4	KCC1	192	K⁺, Cl⁻ cotransporter	19	11	18
SLC20A2	PIT2	182	Na⁺-dependent PO₄³⁻ transporter 2	20	16	21

RNAseq analysis revealing the 20 highest expressed genes encoding plasma membrane transporters and pumps in choroid plexus. TPM: transcripts per million; FACS rank: each gene’s rank in the FACS sample; Female rank: rank in the choroid plexus from female rats

ISSN: 2045-8118