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Table 6 Tumor growth-associated proteins in cyst fluid from cystic glioblastomas

From: Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors

Protein Function in tumor biology N Mean ± SD
SPARCL 1 Glioma cell proliferation and invasion 12 9.0 ± 0.4
IGF-BP 2 Glioma cell invasion. Vasculogenic mimicry 12 8.3 ± 0.6
Kininogen-1/bradykinin Glioma cell migration. Endothelial leakage 12 9.6 ± 0.2
Kallikrein Endothelial leakage. Anti-apoptotic 12 7.9 ± 0.5
Osteopontin Tumor cell migration 12 9.9 ± 0.5
FAM3C Invasion. Proliferation 11 7.9 ± 0.3
TREM2 Glioma cell invasion. Proliferation 9 7.8 ± 0.3
CD166 (secreted) Glioma cell invasion 9 7.7 ± 0.5
Prosaposin Invasion. Anti-apoptotic 7 7.5 ± 0.4
Clusterin (secreted) Anti-apoptotic 12 10.2 ± 0.3
Soluble CD5L Anti-apoptotic 10 8.1 ± 0.5
HYOU1 Anti-apoptotic. Hypoxia adaptation 8 7.7 ± 0.6
HGFA Activates HGF 9 7.7 ± 0.4
HRG Tumor vascularization 12 10.1 ± 0.5
Alpha-2-HS-glycoprotein Tumor vascularization 12 10.1 ± 0.5
LRG Tumor vascularization 12 9.9 ± 0.4
GRP78 (secreted) Tumor vascularization 12 8.6 ± 0.7
MIF Tumor vascularization 9 7.9 ± 0.6
VEGFA Tumor vascularization. Vasculogenic mimicry. Endothelial leakage 8 7.7 ± 0.2
HDGF Tumor vascularization 2 7.8 ± 0.4
Cadherin-5 (soluble) Endothelial leakage. Vasculogenic mimicry 12 8.2 ± 0.8
  1. Cyst fluid from 12 cystic glioblastomas was sampled during tumor surgery and the proteome was analyzed by tandem mass spectrometry. Column “N” gives the number of samples out of 12 with a positive protein identification. Only samples with a positive protein identification were used to calculate mean ± SD values. Protein levels are given as log-10 of the area under the curve as determined by mass spectrometry. Abbreviations: CD5L: CD5-like protein (CD: cluster of differentiation); FAM3C: family with sequence similarity 3; FGF: fibroblast growth factor; GRP78: glucose-regulated protein 78; HDGF: Hepatoma-derived growth factor; HGF: Hepatocyte growth factor; HGFA: Hepatocyte growth factor activator; HRG: histidine-rich glycoprotein; HYOU1: hypoxia up-regulated protein 1; LRG: Leucine-rich α-2-glycoprotein; MIF: macrophage migration inhibitory factor; SPARCL1: secreted, acidic and rich in cysteine-like 1; TREM2: triggering receptor expressed on myeloid cells 2; VEGFA: vascular endothelial growth factor A