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Table 5 Correlations between glioblastoma cyst fluid hormones and serum proteins and the volumes of tumors and cysts and degree of peri-tumoral edema

From: Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors

  Tumor volume Cyst volume Peritumoral edema
r p r p r p
IGF-1 0.11   0.38 0.061 0.08  
Insulin − 0.03   − 0.26   0.60 0.0016
Erythropoietin 0.03   − 0.08   − 0.04  
Growth hormone 0.40 0.046 0.26   0.31  
Testosterone 0.42 0.039 0.35 0.086 − 0.04  
Estradiol 0.36 0.086 0.50 0.011 − 0.08  
Triiodothyronine − 0.18   − 0.14   − 0.27  
SHBG 0.61 0.0014 0.60 0.0014 0.02  
Albumin 0.48 0.015 0.20   0.25  
Apolipoprotein A-I 0.26   0.28   0.02  
  1. Twenty-five cystic glioblastomas were analyzed with respect cyst fluid concentrations of hormones and serum proteins and tumor and cyst volumes and peri-tumoral edema. Data are correlation coefficients (r) and corresponding significant or near-significant p-values (p); Pearson’s test. Abbreviations: IGF-1: insulin-like growth factor 1; SHBG: sex hormone-binding globulin