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Table 5 Correlations between glioblastoma cyst fluid hormones and serum proteins and the volumes of tumors and cysts and degree of peri-tumoral edema

From: Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors

 

Tumor volume

Cyst volume

Peritumoral edema

r

p

r

p

r

p

IGF-1

0.11

 

0.38

0.061

0.08

 

Insulin

− 0.03

 

− 0.26

 

0.60

0.0016

Erythropoietin

0.03

 

− 0.08

 

− 0.04

 

Growth hormone

0.40

0.046

0.26

 

0.31

 

Testosterone

0.42

0.039

0.35

0.086

− 0.04

 

Estradiol

0.36

0.086

0.50

0.011

− 0.08

 

Triiodothyronine

− 0.18

 

− 0.14

 

− 0.27

 

SHBG

0.61

0.0014

0.60

0.0014

0.02

 

Albumin

0.48

0.015

0.20

 

0.25

 

Apolipoprotein A-I

0.26

 

0.28

 

0.02

 
  1. Twenty-five cystic glioblastomas were analyzed with respect cyst fluid concentrations of hormones and serum proteins and tumor and cyst volumes and peri-tumoral edema. Data are correlation coefficients (r) and corresponding significant or near-significant p-values (p); Pearson’s test. Abbreviations: IGF-1: insulin-like growth factor 1; SHBG: sex hormone-binding globulin
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Fluids and Barriers of the CNS

ISSN: 2045-8118