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Table 1 Hormones, serum proteins, and electrolytes in cyst fluid from glioblastomas and from serum

From: Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors

 

Unit

Glioblastoma cyst fluid level (n = 25)

Serum level (n = 15)

Serum reference values

IGF-1

nmol/L

7.3 ± 3.7a

Range: 0–13.7

15.6 ± 4.8

4–22

Insulin

pmol/L

24 ± 31a

Range: 1.4–133

105 ± 43

 ≤ 160

Erythropoietin

IU/L

88 ± 105a

Range: 4.7–402

4.1 ± 2.0

4.3–29

Growth hormone

µg/L

0.2 ± 0.2

Range: 0–0.9

0.1 ± 0.1

 < 0.5

Testosterone (M)

nmol/L

5.0 ± 2.7 (n = 16)b

Range: 0.9–10.1

7.3 ± 3.7 (N = 11)b

4.6–24

Testosterone (F)

nmol/L

0.7 ± 0.4 (n = 9)

Range: 0.2–1.5

0.5 ± 0.3 (n = 4)

 ≤ 1.1

Estradiol (M)

nmol/L

0.22 ± 0.28 (n = 16)a

Range: 0–1.0

0 (n = 11)

0.06–0.14

Estradiol (F)

nmol/L

0.09 ± 0.10 (n = 9)

Range: 0–0.2

0.07 ± 0.10 (n = 4)

 < 0.12

Triiodothyronine

pmol/L

3.2 ± 2.1

Range: 1.0–11.5

3.4 ± 0.7

2.8–7.0

SHBG (M)

nmol/L

19 ± 11 (n = 16)

22 ± 11 (n = 11)

15–90

SHBG (F)

nmol/L

26 ± 9 (n = 9)

35 ± 7 (n = 4)

23–100

Albumin

g/L

28 ± 9a

40 ± 4

38–52

Apolipoprotein A-I

g/L

0.5 ± 0.3a

1.5 ± 0.3

1.0–2.3

Sodium

mmol/L

140 ± 20

139 ± 4

137—145

Potassium

mmol/L

3.8 ± 0.7

4.1 ± 0.5

3.6–4.6

Calcium

mmol/L

1.67 ± 0.47a

2.28 ± 0.15

2.20–2.55

Glucose

mmol/L

1.7 ± 1.3a

6.2 ± 1.1

4.2–6.2

  1. Cyst fluid from 25 glioblastoma patients was analyzed with respect to hormones, serum proteins, electrolytes and glucose. For 15 glioblastoma patients, parallel serum samples were available. Data are mean ± SD values.
  2. All p-values were obtained with Student’s unpaired 2-tailed t-tests, not corrected for multiple comparisons. Serum reference values are from The Oslo University Hospital Hormone laboratory. Testosterone reference values are for men (M) > 41 years and for women (F) > 50 years. Estradiol reference values are for men > 17 years and for women > 50 years. SHBG reference values are for men > 60 years and for women > 18 years. Zero values are below the limits of detection, which were: IGF-1: 1.95 nmol/L, growth hormone: 0.030 µg/L, estradiol: 0.04 nmol/L. Abbreviations: IGF-1: insulin-like growth factor 1; SHBG: sex hormone-binding globulin
  3. asignificantly different from serum values; p < 0.001
  4. bdifferent from corresponding testosterone values in female patients; p < 0.004