From: Experimental approaches for manipulating choroid plexus epithelial cells
Serotype/Capsid | Delivery route | Age at administration | Transductiona | Duration of transgene expression | References | |
---|---|---|---|---|---|---|
ChP | Ependyma | |||||
AAV2/1 | I.C.V.c | E15.5 | Yes | Not tested | Up to 1Â year | [152] |
P0.5b | Yes | Yes | 1Â month | [153] | ||
P0.5b | Yes | Yes | Up to 1Â year | [85] | ||
8–12 weeks | Yes | Yes | 1 year | [154] | ||
8–16 weeks | Yes | Yes | 21 days | [89] | ||
AAV2/2 | I.C.V.c | P0.5b | Not tested | Yes (few) | 1Â month | [153] |
P0.5b | Yes (low) | No | Up to 1Â year | [85] | ||
AAV2/4 | I.C.V.c | P0 or P1 | No | Yes | 4Â weeks | [116] |
4–8 weeks | No | Yes | 4 weeks | [116] | ||
6–8 weeks | Not tested | Yes | 4 weeks | [155] | ||
85Â days | Yes | Yes | Up to 160Â days | [156] | ||
AAV2/5 | I.C.V.c | E10.5 | Yes | Not tested | E16.5 | [53] |
E13.5 | Yes | No | E15.5 | [87] | ||
E13.5 | Yes | No | Up to E18.5 | [53] | ||
E14.5 | Yes | Not tested | P18-P24 | [38] | ||
E15 | Yes | No | 130Â days | [88] | ||
P0.5b | Yes | Yes | Up to 15Â months | [92] | ||
P2-P3 | Yes (specific) | No | Up to P300 | [90] | ||
8–16 weeks | Yes (21 days) | Yes (6 months) | Up to 6 months | [89] | ||
3Â months | Yes (specific) | No | Up to 12Â months | [74] | ||
I.T.d | Adult | Yes | No | 6Â weeks | [93] | |
AAV2/8 | I.C.V.c | 8–16 weeks | Yes | No | 21 days | [89] |
AAV2/9 | I.C.V.c | E15 | Yes | No | 130Â days | [88] |
8–16 weeks | Yes (low) | No | 21 days | [89] |