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Table 2 Overview of AAV vectors delivered to mouse embryonic/neonatal/adult brains

From: Experimental approaches for manipulating choroid plexus epithelial cells

Serotype/Capsid Delivery route Age at administration Transductiona Duration of transgene expression References
ChP Ependyma
AAV2/1 I.C.V.c E15.5 Yes Not tested Up to 1 year [152]
P0.5b Yes Yes 1 month [153]
P0.5b Yes Yes Up to 1 year [85]
8–12 weeks Yes Yes 1 year [154]
8–16 weeks Yes Yes 21 days [89]
AAV2/2 I.C.V.c P0.5b Not tested Yes (few) 1 month [153]
P0.5b Yes (low) No Up to 1 year [85]
AAV2/4 I.C.V.c P0 or P1 No Yes 4 weeks [116]
4–8 weeks No Yes 4 weeks [116]
6–8 weeks Not tested Yes 4 weeks [155]
85 days Yes Yes Up to 160 days [156]
AAV2/5 I.C.V.c E10.5 Yes Not tested E16.5 [53]
E13.5 Yes No E15.5 [87]
E13.5 Yes No Up to E18.5 [53]
E14.5 Yes Not tested P18-P24 [38]
E15 Yes No 130 days [88]
P0.5b Yes Yes Up to 15 months [92]
P2-P3 Yes (specific) No Up to P300 [90]
8–16 weeks Yes
(21 days)
Yes
(6 months)
Up to 6 months [89]
3 months Yes (specific) No Up to 12 months [74]
I.T.d Adult Yes No 6 weeks [93]
AAV2/8 I.C.V.c 8–16 weeks Yes No 21 days [89]
AAV2/9 I.C.V.c E15 Yes No 130 days [88]
8–16 weeks Yes (low) No 21 days [89]
  1. aExpression beyond ChP and ependyma were reported. AAV2/5 shows the greatest tropism for ChP
  2. bP (Postnatal day) 0.5: Day of birth
  3. cI.C.V.: Intracerebroventricular delivery
  4. dI.T.: Intrathecal delivery