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Table 2 Overview of AAV vectors delivered to mouse embryonic/neonatal/adult brains

From: Experimental approaches for manipulating choroid plexus epithelial cells

Serotype/Capsid

Delivery route

Age at administration

Transductiona

Duration of transgene expression

References

ChP

Ependyma

AAV2/1

I.C.V.c

E15.5

Yes

Not tested

Up to 1 year

[152]

P0.5b

Yes

Yes

1 month

[153]

P0.5b

Yes

Yes

Up to 1 year

[85]

8–12 weeks

Yes

Yes

1 year

[154]

8–16 weeks

Yes

Yes

21 days

[89]

AAV2/2

I.C.V.c

P0.5b

Not tested

Yes (few)

1 month

[153]

P0.5b

Yes (low)

No

Up to 1 year

[85]

AAV2/4

I.C.V.c

P0 or P1

No

Yes

4 weeks

[116]

4–8 weeks

No

Yes

4 weeks

[116]

6–8 weeks

Not tested

Yes

4 weeks

[155]

85 days

Yes

Yes

Up to 160 days

[156]

AAV2/5

I.C.V.c

E10.5

Yes

Not tested

E16.5

[53]

E13.5

Yes

No

E15.5

[87]

E13.5

Yes

No

Up to E18.5

[53]

E14.5

Yes

Not tested

P18-P24

[38]

E15

Yes

No

130 days

[88]

P0.5b

Yes

Yes

Up to 15 months

[92]

P2-P3

Yes (specific)

No

Up to P300

[90]

8–16 weeks

Yes

(21 days)

Yes

(6 months)

Up to 6 months

[89]

3 months

Yes (specific)

No

Up to 12 months

[74]

I.T.d

Adult

Yes

No

6 weeks

[93]

AAV2/8

I.C.V.c

8–16 weeks

Yes

No

21 days

[89]

AAV2/9

I.C.V.c

E15

Yes

No

130 days

[88]

8–16 weeks

Yes (low)

No

21 days

[89]

  1. aExpression beyond ChP and ependyma were reported. AAV2/5 shows the greatest tropism for ChP
  2. bP (Postnatal day) 0.5: Day of birth
  3. cI.C.V.: Intracerebroventricular delivery
  4. dI.T.: Intrathecal delivery