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Table 2 Parameter values used for Model 2 (Fig. 4)

From: Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B

Quantity name Initial value Units
Arterial blood 1.16 Liter
S100B 0.00 Nanogram/milliliter
Venous blood 2.33 Liter
S100B 0.00 Nanogram/milliliter
Central lymph 12.00 Liter
S100B 0.00 Nanogram/milliliter
Brain 1.34 Liter
Vascular compartment brain 67.00 Milliliter
S100B 0.00 Nanogram/milliliter
Interstitium brain 130.00 Milliliter
S100B 10.00 Nanogram/milliliter
Glia 0.20 Liter
S100B 50.00 Nanogram/milliliter
Urine 200.00 Milliliter
S100B 0.00 Nanogram/milliliter
Kidney 280.00 Milliliter
S100B 0.25 Nanogram/milliliter
Muscle 31.30 Liter
Interstitium muscle 2.80 Liter
S100B 0.30 Nanogram/milliliter
Vascular space muscle 0.85 Liter
S100B 0.00 Nanogram/milliliter
Adipose 22.70 Liter
Interstitium adipose 3.20 Liter
S100B 0.50 Nanogram/milliliter
Vascular space adipose 703.10 Milliliter
S100B 0.00 Nanogram/milliliter
Gut 1220.00 Milliliter
Vascular space gut 61.00 Milliliter
S100B 0.00 Nanogram/milliliter
Interstitium gut 325.00 Milliliter
S100B 0.18 Nanogram/milliliter
Saliva 10.00 Milliliter
S100B 0.00 Nanogram/milliliter
ArterialToBrainBloodFlow 42,000.00 Milliliter/hour
BrainToVenousBloodFlow 42,000.00 Milliliter/hour
BBB_index 0.00 1/hour
Trauma_index 0.00 1/hour
Glymphatics 8.40 Milliliter/hour
VenousToArterialBloodFlow 201,874.29 Milliliter/hour
LymphaticToVenous 100.00 Milliliter/hour
GFR 10.00 Milliliter/hour
ArterialToKidneyBloodFlow 66,000.00 Milliliter/hour
EliminationFactor 100.00 1/minute
KidneyToVenousBloodFlow 66,000.00 Milliliter/hour
ReverseSigmaGut 0.05 1/hour
ReverseSigmaAdipose 0.05 1/hour
ReverseSigmaMuscle 0.05 1/hour
BBB 100.00 1/minute
SalivaryBloodFlow 1.00 Milliliter/minute
EmptyingSaliva 1.00 Dimensionless
kf 1.00 Dimensionless
kf_1 1.00 Dimensionless
SigmaBrainLymphatic 0.10 Dimensionless
TissuePartitionKidney 0.10 1/minute
ArterialToMuscleBloodFlow 45,000.00 Milliliter/hour
MuscleToVenousBloodFlow 45,000.00 Milliliter/hour
SigmaMuscleInterstitiumVascular 0.05 1/hour
MuscleLymphFlow 90.00 Milliliter/hour
SigmaMuscleLymphatic 0.80 Dimensionless
SigmaAdiposeInterstitiumVascular 0.05 1/hour
ArterialToAdiposeBloodFlow 15,600.00 Milliliter/hour
AdiposeToVenousBloodFlow 15,600.00 Milliliter/hour
SigmaAdiposeLymphatic 0.80 Dimensionless
AdiposeLymphFlow 31.20 Milliliter/hour
GutToVenousBloodFlow 66,000.00 Milliliter/hour
ArterialToGutBloodFlow 66,000.00 Milliliter/hour
SigmaGutInterstitiumVascular 0.05 1/hour
SigmaGutLymphatic 0.80 Dimensionless
GutLymphFlow 132.00 Milliliter/hour