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Table 1 Parameter values used for Model 1 (Fig. 2)

From: Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B

Quantity name Initial value Units
Arterial blood 2500.00 Milliliter
S100B 0.00 Nanogram/milliliter
Brain 1340.00 Milliliter
S100B 9.00 Nanogram/milliliter
Kidney 325.00 Milliliter
S100B 0.25 Nanogram/milliliter
Urine 600.00 Milliliter
S100B 0.00 Nanogram/milliliter
Venous blood 2500.00 Milliliter
S100B 0.00 Nanogram/milliliter
Lung 547.00 Milliliter
S100B 0.37 Nanogram/milliliter
Heart 359.00 Milliliter
S100B 0.28 Nanogram/milliliter
Bone 3950.00 Milliliter
S100B 0.00 Nanogram/milliliter
Adipose tissue 22,700.00 Milliliter
S100B 0.51 Nanogram/milliliter
Skin 3150.00 Milliliter
S100B 0.28 Nanogram/milliliter
Muscle 31,300.00 Milliliter
S100B 0.30 Nanogram/milliliter
Gut 1220.00 Milliliter
S100B 0.40 Nanogram/milliliter
Lymph 12.00 Liter
S100B 0.00 Nanogram/milliliter
Muscle tissue vascular fraction 845.10 Milliliter
S100B 0.00 Nanogram/milliliter
Gut tissue vascular fraction 61.00 Milliliter
S100B 0.00 Nanogram/milliliter
Lung tissue vascular fraction 101.20 Milliliter
S100B 0.00 Nanogram/milliliter
Heart tissue vascular fraction 15.08 Milliliter
S100B 0.28 Nanogram/milliliter
Bone tissue vascular fraction 197.50 Milliliter
S100B 0.00 Nanogram/milliliter
Kidney tissue vascular fraction 22.75 Milliliter
S100B 0.00 Nanogram/milliliter
Skin tissue vascular fraction 157.50 Milliliter
S100B 0.00 Nanogram/milliliter
Adipose tissue vascular fraction 703.70 Milliliter
S100B 0.00 Nanogram/milliliter
Brain tissue vascular fraction 67.00 Milliliter
S100B 0.00 Nanogram/milliliter
BloodFlowLungToArtery 313,980.00 milliliter/hour
BloodFlowVenousToLung 313,980.00 Milliliter/hour
BloodFlowArteryToKidney 66,000.00 Milliliter/hour
BBB_Index 0.00 Dimensionless
GFR 125.00 Milliliter/minute
BloodFlowArteryToSaliva 0.00 1/hour
BloodFlowArteryToVenous 3139.00 Milliliter/hour
BloodFlowArteryToMuscle 45,000.00 Milliliter/hour
BloodFlowArteryToHeart 9000.00 Milliliter/hour
BloodFlowHeartToVenous 9000.00 Milliliter/hour
BloodFlowArterialToBone 15,000.00 Milliliter/hour
BloodFlowBoneToVenous 15,000.00 Milliliter/hour
BloodFlowKidneyToVenous 66,000.00 Milliliter/hour
BloodFlowAdiposeToVenous 15,600.00 Milliliter/hour
BloodFlowArterialToAdipose 15,600.00 Milliliter/hour
BloodFlowSkinToVenous 18,000.00 Milliliter/hour
BloodFlowArterialToSkin 18,000.00 Milliliter/hour
TissueFactor 0.18 Dimensionless
BloodFlowMuscleToVenous 45,000.00 Milliliter/hour
BloodFlowArteryToGut 66,000.00 Milliliter/hour
BloodFlowGutToVenous 66,000.00 Milliliter/hour
LymphFlowMuscle 90.00 Milliliter/hour
LymphFlowGut 132.00 Milliliter/hour
LymphFlowHeart 132.00 Milliliter/hour
LymphFlowAdipose 31.20 Milliliter/hour
LymphFlowSkin 36.00 Milliliter/hour
LymphFlowKidney 132.00 Milliliter/hour
LymphFlowToVein 3100.00 Milliliter/hour
kf_1 1.00 Dimensionless
BloodFlowLungToArterial 313,980.00 Milliliter/hour
Excretion 0.00 1/minute
RenalEliminationFactor 100.00 Dimensionless
kf_brain 0.02 Dimensionless
AdiposeTissueFactor 1.00 Dimensionless
PoreRatioMuscle 2000.00 Dimensionless
PoreRatioAdipose 500.00 Dimensionless
PoreRatioGut 500.00 Dimensionless
PoreRatioSkin 500.00 Dimensionless
PoreRatioLung 45.00 Dimensionless
PoreRatioKidney 200.00 Dimensionless
kr_brain 0.00 Dimensionless
kf_muscle 24.44 Dimensionless
kr_muscle 0.00 Dimensionless
kf_gut 104.17 Dimensionless
kr_gut 0.01 Dimensionless
kf_lung 617.28 Dimensionless
kr_lung 0.06 Dimensionless
kf_heart 130.21 Dimensionless
kr_heart 0.01 Dimensionless
kf_bone 797.10 Dimensionless
kr_bone 0.08 Dimensionless
kf_kidney 135.14 Dimensionless
kr_kidney 0.01 Dimensionless
kf_skin 66.67 Dimensionless
kr_skin 0.01 Dimensionless
kf_adipose 57.14 Dimensionless
kr_adipose 0.01 Dimensionless
interstitialFlow 1.00 Milliliter/hour
BloodFlowFromBrain 42,000.00 Milliliter/hour
BloodFlowToBrain 42,000.00 Milliliter/hour