Fig. 5From: Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100BA Modeling of the CNS and its communications with the periphery. Note the equation numbers referring to the Methods. B Representation of the physiological reality to be modeled and schematics of the CNS components of the model. The dotted lines refer to the permeability of the BBB which is controlled by the BBB_Index. The Glia compartment is at equilibrium with the interstitial levels of S100B via the Trauma_IndexBack to article page