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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B

Fig. 3

Results from simulations and sensitivity analysis (Model 1). The left panel shows the actual levels of S100B in organs before (A BBBD = 0) and after BBB disruption (B) obtained by setting the BBB_Index value to 1. Note the pronounced increase of S100B in venous blood with comparably smaller changes in other compartments. Figures C and D show the results of sensitivity analysis queries under the same conditions. Note that before BBBD (A) venous levels at steady state never reached the 0.1 ng/ml thresholds, the upper ceiling for control values of S100B. The x axis in the bar plots specifies the sensitivity inputs and y axes the sensitivity outputs integrated over time

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