Fig. 1

Schematic representation of the structure of Model 1. The continuous red lines depict flow through arteries (except for the lung), while the continuous blue lines refer to venous flow. The dotted blue lines show the lymphatic vessels connecting the organs directly to the venous compartment. The right panel inset shows a graphical representation of the mechanism of BBBD presented herein, underscoring that venous levels are greatly influenced by leakage of biomarkers from the brain into the circulation