Skip to main content
Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF

Fig. 5

In vivo cerebrospinal fluid (CSF)-to-brain parenchyma transfer of [14C]creatine after intracerebroventricular injection. A Time-course of [14C]creatine concentration in the CSF after intracerebroventricular administration. The residual CSF concentration is the percentage of the dose remaining in 1 mL CSF. B CSF-to-brain parenchyma transfer of [14C]creatine after intracerebroventricular injection. An extracellular fluid buffer containing [14C]creatine (877 pmol/10 µL) was directly injected into the CSF. The solid line was fitted using a nonlinear least-squares regression analysis program. Each open circle represents an individual data point. Each central bar represents the mean ± S.D. (n = 3)

Back to article page

Fluids and Barriers of the CNS

ISSN: 2045-8118