Fig. 4

Characterization of local defects in tissue-engineered iBMEC microvessels in response to chronic and acute oxidative stress. a Representative examples of the three defect types: delamination, focal leak, and combination focal leak/delamination. White arrows indicate delaminations and blue arrows indicate focal leaks. b Distribution of defect types in chronic and acute exposure over time. c Representative images showing resolution of a delamination defect over one day following acute exposure. d Histogram of persistence of delaminations under chronic and acute stress exposure. e, f Distribution of delamination sizes and distance to nearest defect under chronic and acute exposure to oxidative stress over time. Data (b, d–f) represents n = 124 defects across both conditions with n = 3 independent microvessels for each condition