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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited

Fig. 4

Water permeation pathways observed in cryo-EM structures of hNKCC1 and hSGLT1. A Sphere representation of selected water molecules in an apparent permeation pathway though the hNKCC1, figure from Supplementary data in [142]. The permeation pathway ends in a vestibule which contains about 40 water molecules. B Water permeation pathway in hSGLT1, illustrated by a representative simulation frame. Water molecules in red and white, figure from [143]

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