Table 3 ADCY functions and their associated diseases

ADCY1

Yes^a

Yes

Learning, memory, LTP, synaptic plasticity, drug dependency, nociception, and pain

Anxiety-like behavior, hearing impairment, sleep deprivation, schizophrenia, bipolar disorder, and autism

[28, 50, 53, 55,56,57]

ADCY2

–

–

Synaptic plasticity and neuropsychiatric functions

Bipolar disorder, anxiety, stress-like disorders, Lesch-Nyhan disease, and schizophrenia

[63,64,65,66]

ADCY3

Yes^a,b

–

Odorant signaling, learning, and memory

Obesity, depression, and inflammatory bowel disease

[19, 38, 68, 70,71,72, 74,75,76,77,78,79, 190]

ADCY4

Yes^b

–

–

–

[81]

ADCY5

Yes^a,c

Yes

Learning, memory, synaptic plasticity, and extrapyramidal motor functions

Familial dyskinesia and facial myokymia, anxiety, depressive-like disorder, and movement disorders

[83,84,85, 89, 92,93,94,95]

ADCY6

Yes^a

Yes

Metabolic functions and fluid homeostasis in kidney

Axoglial diseases and lethal congenital contracture syndrome

[97, 98, 100, 101]

ADCY7

Yes^c

Yes

Alcohol dependency

Depression-like disorder, inflammatory bowel disease, Crohn’s disease, ulcerative colitis, and autoimmune diseases

[42, 108, 109]

ADCY8

Yes^a

Yes

Learning, memory, LTP, synaptic plasticity, nociception, and pain

Dissociative amnesia, post-traumatic stress disorder, depression, and bipolar disorder

[29, 33, 37, 52, 112, 113]

ADCY9

Yes^a

Yes

Learning and memory, immunological functions, and cardioprotective

Asthma, mood disorders, and bipolar disorder

[116, 119,120,121]

ADCY10

Yes^a

–

Synaptic plasticity, learning and memory, ocular dominance plasticity, and fertilization

Infertility and absorptive hypercalciuria

[126, 132, 133]