Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus

Table 3 Summary of baseline in vivo brain compartment volumes across p73^+/+ control and p73^−/− groups

Dependent variable	p73^+/+ (N = 8)		p73^−/− (N = 7)		Difference	SE	p-value	L95%	U95%
Dependent variable	Mean	SE	Mean	SE	Difference	SE	p-value	L95%	U95%
Total intracranial volume (TIV) mm³	453.3	6.3	362.3	6.6	91.0	9.1	< 0.001	71.3	110.8
Brain parenchymal volume (mm³)	442.7	7.0	333.8	5.2	107.8	8.4	< 0.001	89.5	125.9
Cerebral ventricle volume mm³	4.4	0.4	26.3	2.9	− 21.9	2.9	< 0.001	− 29.0	− 14.7
CV volume fraction of TIV (%)	0.98	0.08	7.3	0.8	− 6.3	0.8	< 0.001	− 8.3	− 4.3
Olfactory bulb volume (mm³)	19.2	0.5	7.7	0.5	11.5	0.7	< 0.001	10.0	13.0

Data are presented as means and SE’s; Mean differences compare p73^+/+ control vs. p73^−/− groups for each dependent variable using a two-sided independent samples t-test. L95%: lower limit of 95% confidence interval for mean (CI), U95%: upper limit of 95% CI
p-values marked with bold indicate that the mean difference is significant at the 0.05 level.
CV: Cerebral ventricle

ISSN: 2045-8118