Fig. 4

Drainage from CNS to the deep cervical lymph nodes is sustained in ciliopathy. A, B T1 maps of drainage to the deep cervical lymph nodes (dcLN) from a CEP164^fl/fl mouse and a ciliopathy FOXJ1-Cre;CEP164^fl/fl mouse. The drainage maps are color coded as T1 values in the range of 1–1700 ms, confined (masked) to the areas corresponding to the dcLN and overlaid onto the corresponding anatomical brain scans. Note that red and blue colors indicate low and high T1 values, respectively. C, D Corresponding T1 maps of drainage to the dcLN from a p73^+/+ control mouse and a p73^−/− ciliopathy mouse. E Graphs with quantification of Gd-DOTA drainage to the dcLN (quantified as the volume of voxels with a T1 value in the range of 1–1700 ms) and the corresponding dcLN volumes across CEP164^fl/fl and FOXJ1-Cre;CEP164^fl/fl mice. Data are mean ± SEM. Graphs with quantification of Gd-DOTA drainage to the dcLN as well as the dcLN volumes across p73^+/+ and p73^−/− mice. Data are mean ± SEM. *p-value = 0.012