Fig. 2
Glymphatic transport is sustained in FOXJ1-Cre;CEP164fl/fl and increased in p73−/− mice. A, B Representative color coded glymphatic transport T1 maps (brain parenchymal compartment) from a CEP164fl/fl and a FOXJ1-Cre;CEP164fl/fl mouse. Red and blue colors represent low and high T1 values, respectively. Note that low and high T1 values represent tissue areas with high and low glymphatic transport, respectively. C Graph with quantification of total glymphatic transport in % of total intracranial volume (TIV) across CEP164fl/fl and FOXJ1-Cre;CEP164fl/fl mice. Data are mean ± SEM. ns = no significant difference across the groups. D, E Color coded glymphatic transport maps (% of TIV) from a p73+/+ and a ciliopathy p73−/− mice. F Graph with quantification of total glymphatic transport (% of TIV) between p73+/+ and p73−/− mice. Data are mean ± SEM. **p-value = 0.006. Note the hypoplastic olfactory bulb in both ciliopathy mouse models. Olf: Olfactory bulb; cb: cerebellum; aq: aqueduct