Fig. 1
From: Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
A The 18F-THK5351Ventricular CSF(t) time activity curve (TAC) and the image-derived arterial blood curve, averaged over all subjects. The tracer TAC peaked approximately within 2 min after injection. The lines marked a, b, c, d correspond to the sampled time points for vCSF-SLOPE and to the images of the four time frames shown in (B). standardized uptake value (SUV). B The four images from one AD subject demonstrate the changes in 18F-THK5351 SUV in the lateral ventricle superimposed on the coregistered MRI. Color maps and the corresponding color bar (SUVR) depict the decreasing CSF levels of the tracer at 1, 10, 30 and 60 min