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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders

Fig. 2

Summarized mechanisms of BBB regulatory miRNAs, lncRNAs, and circRNAs in CNS disorders. MiRNAs, lncRNAs, and circRNAs modulate the integrity of BBB through different mechanisms, including direct or indirect modulation of tight junction proteins, adherens junction proteins, MMPs, water channel-related proteins, angiogenesis-related proteins, inflammation-related factors, apoptosis-related molecules, oxidative stress-related factors, autophagy-related proteins, and others, in endothelial cells, pericytes, or astrocytes of the CNS. LncRNAs and circRNAs primarily act as microRNA “sponges” or competing endogenous RNAs to regulate BBB damage and recovery in CNS diseases

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Fluids and Barriers of the CNS

ISSN: 2045-8118