Table 1 Composition of the different NLCs used in the study
Formulation name | Liquid lipid | Surface modification | Entrapped molecule (%) w/w | Cell model to perform functional assays |
|---|---|---|---|---|
CS-NLC-DiD | DHAH | CS | DiD (0.5) | hiPSCs derived BMECs |
TAT-CS-NLC-DiD | DHAH | CS and TAT | DiD (0.5) | hiPSCs derived BMECs |
Miglyol-NLC | Miglyol | CS and TAT | - | Microglial cell line—HMC3 |
DHAH-NLC | DHAH | CS and TAT | – | Microglial cell line—HMC3 |
DHAH-NLC-GDNF | DHAH | CS and TAT | GDNF (0.125) | Microglial cell line—HMC3 |
DHAH-NLC-VEGF | DHAH | CS and TAT | VEFG (0.125) | Microglial cell line—HMC3 |