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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter

Fig. 3

Increase of cell death and reduction of oligodendrocytes in the PVWM after induction of hydrocephalus. A The number of positive cells for cleaved caspase-3, which labels cell death, was found to increase in the PVWM adjacent to the body of the lateral ventricles in hydrocephalic (hydro) pigs compared with sham control (sham) pigs. B, C Representative images illustrating the increase of cell death in the PVWM adjacent to the body of the hydrocephalic pigs. Magnifications are the same. D In addition, the hydrocephalic pigs showed a reduction of Olig2+ cell density in the PVWM from both areas adjacent to the lateral ventricles. E, F Representative images used for quantification of Olig2+ in sections from both groups showing the decrease of oligodendrocytes in the PVWM adjacent to the body of the hydrocephalic pigs. Magnifications are the same. Scale bars represent 20 µm for caspase-3 and 10 µm for Olig2. Images were obtained under the fluorescent microscope. Means with 95% confidence intervals are shown. *p = 0.026; **p = 0.0095 in the frontal horn and **p = 0.0087 in the body, Wilcoxon–Mann–Whitney test

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Fluids and Barriers of the CNS

ISSN: 2045-8118