Fig. 8

Schematic of spinal cord inflow. Respiration, specifically cyclical fluxes in intrathoracic pressure (spontaneous breathing) drive transpial fluid flow into the spinal white matter as well as perivascular fluid flow in the grey matter. Hypertension and tachycardia had little effect on transpial transport. It is possible that perivascular flow is also unchanged. However, there is increased tracer movement from perivascular spaces into the spinal interstitium, predominately in the grey matter. Arrow length and direction indicate displacement and velocity of solute/fluid particles. ASA anterior spinal artery, SAS subarachnoid space