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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord

Fig. 5

Adjunctive analysis of spinal interstitial inflow. A, B The number of fluorescent “perivascular events” within the grey matter (arrows) was assumed to represent deposits of fluorescent ovalbumin (AFO-647) around perivascular spaces of central arteriolar, venular or capillary branches, a measure of central cord inflow. C In spontaneous breathing (SB) rats, there were greater number of “events” compared with control groups, with C2 and C3 reaching significance on post hoc analysis. E More “events” were found in the Low MAP Control group than in hypertensive rats. G There was no difference between the tachycardic animals and either control groups. D, F, H A measure of central spinal cord inflow was “grey matter %” (the aggregate area of “perivascular events” as a percentage of the total grey matter area). D SB was the only variable that resulted in significantly greater “grey matter %” compared with controls. F There was a significant reduction in “grey matter %” in hypertensive animals. H Tachycardia resulted in no difference compared with controls. Two-way analysis of variance (ANOVA) post hoc Bonferroni’s, (*) denotes significance to Control animals, (†) denotes significance to Normal controls, *p < 0.05, **p < 0.01, ****p < 0.0001. All error bars are expressed as ± SEM, n = 6/7 rats

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