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Table 2 Correlation coefficients of CSF biomarkers of T-tau, P-tau181, NfL, Aβ-isoforms (38, 40, 42), sAPPα, sAPPβ and MCP1 among with the APOE-genotype, age, MMSE and gait velocity

From: Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients

Pearson correlation coefficients (r)

P-tau

NfL

Aβ38

Aβ40

Aβ42

sAPPα

sAPPβ

MCP1

APOE

Age

MMSE Pre-op

MMSE Post-op

MMSE Outcome

Gait Pre-op

 

T-tau

T-tau

               

P-tau

.904**

              

NfL

.501**

.300**

             

Aβ38

.624**

.708**

.157

            

Aβ40

.622**

.720**

.156

.964**

           

Aβ42

.291**

.365**

.128

.771**

.784**

          

sAPPα

.414**

.505**

.114

.638**

.645**

.481**

         

sAPPβ

.412**

.511**

.053

.647**

.639**

.442**

.926**

        

MCP1

.355**

.324**

.249**

.296**

.288**

.229**

− .024

.021

       

APOE

− .058

− .008

− .042

− .051

− .050

− .268**

− .001

.004

− .144

      

Age

.320**

.268**

.125

.317**

.370**

.194*

.194*

.181*

.087

.036

     

MMSE Pre-op

− .364**

− .263**

− .231**

− .092

− .127

− .016

.011

.021

− .025

− .018

− .185*

    

MMSE Post-op

− .372**

− .300**

− .228**

− .038

− .067

.107

.036

.079

.030

− .049

− .069

.731**

   

MMSE Outcome

− .177*

− .141

− .173*

.090

.086

.179*

.120

.147

.048

− .076

− .013

− .114

.595**

  

Gait Pre-op

− .155

− .143

− .251**

− .128

− .182*

− .194*

− .077

.001

− .012

.159

− .314**

.430**

.246**

− .057

 

Gait Post-op

− .325**

− .249**

− .253**

− .137

− .189*

− .096

.025

.084

− .076

− .068

− .354**

.529**

.491**

.143

.787**

  1. Significant results are highlighted by asterisk (*p < 0.05, **p < 0.01). APOE-correlation is analyzed by scaling the allele combinations by the risk (22 = 1, 23 = 2, 33 = 3, 24 = 4, 34 = 5, 44 = 6). CSF: cerebrospinal fluid; MMSE: mini mental state examination; Gait: gait velocity in m/s; Pre-op: preoperative; Post-op: postoperative; APOE: apolipoprotein E; T-tau: total tau protein; P-tau: phosphorylated at threonine 181 tau protein; NfL: neurofilament-light; Aβ38: Amyloid-β 38; Aβ40: Amyloid-β 40; Aβ42: Amyloid-β 42; sAPPα: soluble amyloid precursor protein α; sAPPβ: soluble amyloid precursor protein β, MCP1: monocyte chemoattractant protein 1