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Table 1 Patient characteristics

From: Cerebrospinal fluid biomarkers that reflect clinical symptoms in idiopathic normal pressure hydrocephalus patients

Patient characteristics

Finnish cohort

Swedish cohort

n = 65

n = 82

p-value

Age (y); mean (SD)

72.4 (7.4)

73.0 (7.2)

0.60

Male sex; n (%)

37 (57)

53 (65)

0.34

Weight (kg); mean (SD)

79.2 (15.4)

79.2 (19.8)

0.99

Height (cm); mean (SD)

168.4 (7.8)

169.1 (18.8)

0.79

Diabetes mellitus T2; n (%)

24 (38)

19 (24)

0.099

Hypertonia; n (%)

41 (63)

44 (54)

0.29

Cardiac disease; n (%)

21 (32)

26 (32)

0.98

MMSE; mean (SD)

   

 Pre-op

22.6 (4.2)

23.6 (4.4)

0.16

 Post-op

22.8 (5.4)

23.9 (5.7)

0.22

Gait velocity (m/s); mean (SD)

   

 Pre-op

0.60 (0.26)

0.66 (0.27)

0.26

 Post-op

0.80 (0.31)

0.84 (0.36)

0.51

APOE- genotype; n (%)

  

0.32

 ε2/ε2

0 (0)

1 (1.9)

 

 ε2/ε3

7 (10.9)

5 (9.3)

 

 ε2/ε4

3 (4.7)

4 (7.4)

 

 ε3/ε3

42 (65.6)

26 (48.1)

 

 ε3/ε4

10 (15.6)

16 (29.6)

 

 ε4/ε4

2 (3.1)

2 (3.7)

 

NPHGS improvement; n (%)

34 (52)

  

NPHS improvement; n (%)

 

48 (59)

 

Biomarkers

   

T-tau (ng/l); mean (SD)

222.0 (111.4)

244.9 (130.5)

0.28

P-tau (ng/l); mean (SD)

30.5 (12.2)

31.9 (12.4)

0.50

NfL (ng/l); mean (SD)

1573.8 (1661.5)

1717.3 (1962.8)

0.64

Aβ38 (ng/l); mean (SD)

1471.4 (515.0)

1526.0 (518.9)

0.53

Aβ40 (ng/l); mean (SD)

3697.5 (1161.4)

3799.8 (1193.5)

0.60

Aβ42 (ng/l); mean (SD)

367.4 (151.4)

364.3 (137.8)

0.90

sAPPα (ng/l); mean (SD)

416.6 (212.7)

446.2 (177.6)

0.37

sAPPβ (ng/l); mean (SD)

305.2 (142.2)

321.0 (121.1)

0.47

MCP1 (ng/l); mean (SD)

463.2 (122.1)

492.2 (109.4)

0.13

  1. Patient characteristics of Finnish and Swedish cohorts presented as mean and standard deviation (SD) or as number and percent. P values are analyzed between the cohorts using t test for continuous variables and chi-square for categorical variables. T2: Diabetes mellitus type 2; MMSE: mini mental state examination; Pre-op: preoperative; Post-op: postoperative; APOE: apolipoprotein E; NPHGS: normal pressure hydrocephalus grading scale; NPHS: normal pressure hydrocephalus scale; T-tau: total tau protein; P-tau: phosphorylated at threonine 181 tau protein; NfL: neurofilament-light; Aβ38: Amyloid-β 38; Aβ40: Amyloid-β 40; Aβ42: Amyloid-β 42; sAPPα: soluble amyloid precursor protein α; sAPPβ: soluble amyloid precursor protein β, MCP1: monocyte chemoattractant protein 1