Fig. 4

Pre-and postoperative Mini Mental State Examination results grouped by P-tau₁₈₁ concentrations. Longitudinal change of pooled MMSE results with CSF P-tau₁₈₁ derived grouping presented in chart. Cutoff used for grouping was 27.5 ng/l. Low P-tau₁₈₁ group presented as triangles and high P-tau₁₈₁ group as circles. Significant results are presented by asterisk (*p < 0.001). MMSE, mini mental state examination; Pre-op: preoperative; Post-op: postoperative; P-tau: phosphorylated at threonine 181 tau protein