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Table 2 Summary of changes in the ultrastructure of l-ornithine treated cultured brain capillary endothelial cells

From: Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells

Cultured brain endothelial cells Control l-ornithine
Number of images analyzed 29 48
Luminal membrane Smooth 74% 67%
Protrusions 26% 33%
Glycocalyx Continuous 89% 29%
Discontinuous 11% 71%
Tight junctions Intact 100% 78%
Discontinuous 0% 22%
Mitochondria Intact 97% 53%
Altered 3% 47%
Vesicular profiles / image Luminal membrane 5.9 ± 4.3 8.7 ± 4.5*
Abluminal membrane 2.2 ± 1.5 5.9 ± 3.8***
Vesicular profiles ratio Luminal membrane 73% 60%
Abluminal membrane 27% 40%
Vacuolization Present 14% 27%
  1. Values are shown in percentage or ratio of the analyzed images in the groups. Vesicular profile: mean ± SD, unpaired t-test; *, p < 0.05; ***, p < 0.001