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Table 2 Summary of changes in the ultrastructure of l-ornithine treated cultured brain capillary endothelial cells

From: Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells

Cultured brain endothelial cells

Control

l-ornithine

Number of images analyzed

29

48

Luminal membrane

Smooth

74%

67%

Protrusions

26%

33%

Glycocalyx

Continuous

89%

29%

Discontinuous

11%

71%

Tight junctions

Intact

100%

78%

Discontinuous

0%

22%

Mitochondria

Intact

97%

53%

Altered

3%

47%

Vesicular profiles / image

Luminal membrane

5.9 ± 4.3

8.7 ± 4.5*

Abluminal membrane

2.2 ± 1.5

5.9 ± 3.8***

Vesicular profiles ratio

Luminal membrane

73%

60%

Abluminal membrane

27%

40%

Vacuolization

Present

14%

27%

  1. Values are shown in percentage or ratio of the analyzed images in the groups. Vesicular profile: mean ± SD, unpaired t-test; *, p < 0.05; ***, p < 0.001