Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus

Table 5 Coefficients from a linear regression model for each CSF marker with preoperative symptoms at baseline as outcome and the covariates age, sex and Evan´s index

CSF marker	Total iNPH scale	Motor domain	Cognitive domain	Balance domain	Continence domain	MMSE
NfL	− 4.24 ***	− 5.23***	-1.80	− 3.73*	− 4.65**	− 0.66
T-tau	− 0.24	0.50	1.63	− 0.15	− 1.54	− 0.32
P-tau	3.26*	4.57*	3.42	− 0.78	4.31*	− 0.22
Aβ1–42	0.86	− 0.32	8.24***	1.42	0.73	1.62***

CSF cerebrospinal fluid, iNPH idiopathic normal pressure hydrocephalus, NfL neurofilament light protein, T-tau total tau, P-tau phosphorylated tau, Aβ1–42 amyloid beta1–42
Bold numbers are significant. * < 0.05; ** < 0.01; *** < 0.001

ISSN: 2045-8118