Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus

Table 4 Four OPLS predicting outcome 12 months after shunt surgery

Variables:	R2Y	Q2	pR2Y	pQ2
1. Base	0.192	0.156	0.01	0.01
2. Base + Evans’ index + DESH	0.203	0.16	0.01	0.01
3. Base + CSF markers	0.22	0.151	0.01	0.01
4. Base + Evans + DESH + CSF markers	0.231	0.157	0.01	0.01

The first model (1) based on basic clinical data (base) including: age, sex, waiting time for shunt surgery, iNPH score at baseline and presence the comorbidities: diabetes mellitus, hyperlipidemia, hypertension and previous stroke or myocardial infarction; (2) basic data with the addition of the imaging markers Evans’ index and DESH; (3) basic data with addition of levels of markers in CSF (NfL, T-tau, P-tau and Aβ1-42), and (4) finally all above listed variables together
iNPH idiopathic normal pressure hydrocephalus, NfL neurofilament light protein, T-tau total tau, P-tau phosphorylated tau, Aβ1–42 amyloid beta-42, DESH disproportionately enlarged subarachnoid-space hydrocephalus

ISSN: 2045-8118