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Table 3 A linear model was built for each predictor relative to the outcome 12 months postoperative change on the iNPH scale (delta iNPH scale) at follow-up and the covariates age, sex, waiting time for shunt surgery, iNPH scale score at baseline and Evans’ index

From: Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus

 

Coefficient

Analysis of variance

P-value

NfL (n = 187)

− 3.10

0.016

T-tau (n = 364)

− 2.45

0.012

P-tau (n = 362)

− 0.62

0.65

Aβ1–42 (n = 363)

2.76

0.058

DESH (n = 376)

4.30

0.055

Covariates:

  

Age

− 0.50

 < 0.001

Sex

− 1.39

0.42

Time to shunt

− 6.03

 < 0.001

iNPH scale baseline

− 0.23

 < 0.001

Evans´ index

20.08

0.33

  1. iNPH idiopathic normal pressure hydrocephalus, NfL neurofilament light protein, T-tau total tau, P-tau phosphorylated tau, Aβ1–42 amyloid beta-42; DESH disproportionately enlarged subarachnoid-space hydrocephalus
  2. Bold numbers are significant
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Fluids and Barriers of the CNS

ISSN: 2045-8118