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Table 2 Median CSF biomarker levels in all patients and proportion of patients with levels outside reference range in the whole sample and in patients with postoperative improvement

From: Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus

 

n

Median (IQR)

Outside reference range, n (%)

Outside reference range among shunt responders1, n (%)

NfL, ng/L

234

1175 (850–1970)

67 (29)

25 (22)

T-tau, ng/L

442

200 (145–282)

73 (17)

29 (14)

P-tau, ng/L

436

29 (23–37)

30 (7)

12 (6)

Aβ1–42, ng/L

438

536 (386–695)

215 (49)

93 (45)

  1. CSF cerebrospinal fluid, NfL neurofilament light protein, T-tau total tau, P-tau phosphorylated tau, Aβ1–42 amyloid beta1-42, IQR interquartile range
  2. Normal reference ranges: Aβ1–42: > 530 ng/L; NfL: 40–60 years, < 890 ng/L, > 60 years, < 1850 ng/L; T-tau: < 350 ng/L; P-Tau: < 60 ng/L
  3. 1Improvement ≥ 5 points on iNPH scale 12 months after shunt surgery