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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus

Fig. 3

OPLS model with both base variables, comorbidity, imaging markers and CSF biomarkers included, built on prediction of outcome 12 months after shunt surgery (delta iNPH scale). The upper left image shows the score plot that illustrate the sample separation, predictive component along the x-axis and orthogonal component along y-axis. The samples are colored according to their delta iNPH value at 12 months. The upper right image shows the loading plot, with the predictive component shown along the x-axis. Variables to the left (with decreasing values) are more associated with negative outcome while variables to the right are associated with positive outcome after shunt surgery. In the bottom, VIP-values illustrating the predictive effect of each variable included in the model. iNPH at baseline refers to preoperative iNPH scale score; DESH disproportionately enlarged subarachnoid-space hydrocephalus, NfL neurofilament light protein, T-tau total tau, P-tau phosphorylated tau, Aβ1–42 amyloid beta1–42

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