Fig. 4

Administration of Met-R preserved blood–brain barrier integrity, but did not affect hemorrhage volume at 24 h after ICH in mice. A Evans blue dye extravasation and B hemorrhage volume assessment 24 h following surgery in sham, vehicle-treated ICH, and Met-R (0.5 μg/kg/day)-treated ICH groups. C, D-G Representative western blot images and quantitative analyses of albumin, claudin-5, occludin, and ZO-1 in sham, vehicle-treated ICH, and Met-R (0.5 μg/kg/day)-treated ICH groups. Data were expressed as mean ± SD or median with range. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. sham; ^#p < 0.05 ^##p < 0.01, ^###p < 0.001 vs. vehicle; n = 6/group