Skip to main content

Table 2 Summary of injection parameters simulated

From: Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology

Description

Name

Location

Injection flow rate (mL/min)

Injection bolus volume (mL)

Flush volume (mL)

CSF Stroke Volume (mL)

Respiration

Lumbar Puncture (baseline)

LP

L3/4

5

5

0

1

NA

Cisterna Magna

CM

FM/C1

5

5

0

1

NA

IntraCerebroVentricular

ICV

FM/C1

5

5

0

1

NA

Lumbar puncture with 5X higher Bolus Rate

5X-Bolus rate

L3/4

25

5

0

1

NA

Lumbar puncture with 3X higher Bolus Volume

3X-Bolus volume

L3/4

5

15

0

1

NA

Lumbar puncture with 2X higher stroke volume

2X-Stroke volume

L3/4

5

5

0

2

NA

Lumbar puncture with 5 mL flush after injection

5 mL-Flush

L3/4

5

5

5

1

NA

Lumbar Puncture with deep respiration waveform super imposed on cardiac flow waveform

Deep respiration

L3/4

5

10

0

1

Yes