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Table 1 Summary of previous in silico and in vivo CSF solute transport studies conducted in the literature to investigate the impact of physiology, injection protocol, and injection location (↓: indicates a decrease in tracer transport to the brain, ↑: increased, ↔ : not changed, ✓: indicates one simulation performed)

From: Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology

Author et al. (year)

Physiology

Injection protocol

Injection location

Heart rate

Stroke volume

Respiration

Bolus volume

Bolus rate

Flush

LP

CM

ICV

CFD

Khani (current)

 

↑

↑

↑

↓

↑

✓

↑

↑

Tangen (2017) [47]

↑

  

↑

 

↑

✓

  

Kuttler (2010) [24]

    

↓

 

✓

  

Haga (2017) [36]

    

↑

 

✓

  

Hsu (2012) [48]

↑

↑

    

✓

  

Myers (1996) [26]

    

↓

 

✓

  

In vivo

Watts (2019) [38]

      

✓

  

Verma (2020) [8]

  

↑

↑

  

✓

  

Ringstad (2018) [49]

      

✓

  

Whiteside (2001) [50]

      

✓

  

Malinovsky (1999) [51]

   

↑

  

✓

  

Sullivan (2020) [52]

   

↑

  

✓

  

Ringstad (2018) [49]

      

✓

  

Wolf (2016) [40]

   

↑

 

↑

✓

↑

 

Meyer (2015) [41]

      

✓

 

↑

  1. LP Lumbar Puncture, CM Cisterna Magna, ICV IntraCerebroVentricular