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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology

Fig. 5

CFD results for 3D tracer concentration profiles versus time for lumbar puncture, cisterna magna and Intracerebroventricular injection. a Visualization of tracer concentration before injection starts at time = 0 min. b–d Visualization of tracer concentration at 5, 15, 60, and 180 min under lumbar puncture, cisterna magna and Intracerebroventricular injection, respectively. b1, b2 Visualization of tracer concentration at 10, 30, and 60 (s) under lumbar puncture injection for CFD simulation and in vitro experiment, respectively. e Visualization of tracer concentration at 5, 15, 60, and 180 min inside ventricular system and the cranial SAS for Intracerebroventricular injection

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Fluids and Barriers of the CNS

ISSN: 2045-8118