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Table 2 EB concentrations on cerebrospinal fluid with multiple stimulation strategy

From: Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse

Multiple stimulation strategy

Drug concentration in the CSF (%)

Locations

Pulse(s)

FSW

Control

 

C

1

0.39 ± 0.06

0.04 ± 0.04

**

C

10

5.58 ± 2.23

 

**

A-B-C

1

1.28 ± 0.53

 

**

CL-CR

1

1.73 ± 0.47

 

**

  1. **, p < 0.01 vs. control, in one-way ANOVA with the Tukey post hoc test (n = 5)
  2. Sampling time: at 3 h after the FSW-treatment
  3. Unit: %, CSF/blood Evans blue concentration
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Fluids and Barriers of the CNS

ISSN: 2045-8118