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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse

Fig. 6

a Histological sections and b H&E stains on S3 after applying the FSW technique at different positions and for different iterations. Red arrows: the BCSFB and BBB opening regions; Blue arrow: the red blood cell extravasations; Black arrow: the bleeding; C: single FSW pulse at position C; C10: 10 FSW pulses at position C; A-B-C: single FSW pulses at positions A, B and C; CL-CR: a single FSW pulse at position C on both hemispheres. The shockwave pulses were administered at an intensity level of 0.1. The indicator was 3% Evans blue (predissolved in 0.9% saline). The scale bar on (a) and (b) respectively represents 5 mm and 100 μm (n = 5)

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