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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse

Fig. 3

a Fluorescence images of a top view of a rat brain following FSW-induced BCSFB opening and the locations of the slices used for histological sectioning. b Histological sections at S3 stained with anti-FITC and hematoxylin for an animal treated with FSW at position C and an animal that did not receive FSW treatment (control, Con.). c Fluorescence images of histological sections (S7–S9) for the rat treated with FSW at position C and the control rat. d Histological sections at S7 and S9 stained with anti-FITC and hematoxylin for the animal treated with FSW at position C and the control animal. e H&E stains of position C (S4) and position E(S6). Black arrow: the choroid plexus. f Fluorescence images of histological sections S1–S6 after FSW treatment at position G. Fluorescence is exhibited locally since the FITC indicator cannot enter the CSF circulation. The sampling time was 3 h after FSW treatment. g Evans blue persistence in the CSF after FSW-BCSFB opening (FSW treatment at position C), FSW-BBB opening (FSW treatment at position G) or control treatment (no FSW treatment). The CSF sampling time is at 3.5 h after the FSW-treatment. *p, #p < 0.05 vs. control and BBB opening, respectively; **p, ##p < 0.01 vs. control and BBB opening, respectively. In one-way ANOVA with the Tukey post hoc test (n = 5)

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