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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse

Fig. 2

a Top view of FSW target positions on a rat brain. b Side view of FSW target positions on a rat brain. Positions A–C are respectively 4 mm, 0 mm, and − 4 mm anterior, and 3 mm lateral to the bregma. Position D is − 4 mm anterior and 6 mm lateral to the bregma. Positions E and F are respectively 12 mm and 16 mm posterior to the bregma. The depth of positions A–F and G relative to the surface of the brain are respectively 5 mm and 1 mm. The blue area corresponds to the ventricles in the brain. The focal dimensions (− 6 dB) of the shockwave at an intensity level of 0.1 (peak positive pressure 5.4 MPa; peak negative pressure − 4.2 MPa; energy flux density 0.03 mJ/mm2) are 3.8 mm in the x-axis, 3.8 mm in the y-axis, and 13.0 mm in the z-axis

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