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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo

Fig. 6

Pericyte- but not astrocyte HIF-1 LoF modulates barrier permeability during hypoxia. Hypoxia-induced changes in brain vascular permeability as measured by A brain water content, B Evans blue and C Lucifer Yellow dye extravasation into brain tissue of SMMHC-CreERT2; HIF-1αfl/fl mice treated with oil (Ctrl) or tamoxifen (LoF) after 96 h normoxia (Nx, 21% O2) or hypoxia (Hx, 8% O2). Brain water content changes in (D) GFAP-CreERT2; HIF-1αfl/fl and (E) GLAST-CreERT2; HIF-1αfl/fl control or LoF mice after normoxic or hypoxic exposure. (F) Lucifer Yellow dye extravasation into brain tissue of GLAST-CreERT2; HIF-1αfl/fl mice. Two-way ANOVA, mean ± SD, n = 5 -8, *p < 0.05, **p < 0.01, compared to Nx Ctrl and Nx LoF, δp < 0.05, δδp < 0.01 compared to Hx Ctrl

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Fluids and Barriers of the CNS

ISSN: 2045-8118