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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Chronic effects of blast injury on the microvasculature in a transgenic mouse model of Alzheimer’s disease related Aβ amyloidosis

Fig. 2

Reduced perivascular AQP4-expressing astrocytic end-feet after bTBI in APP/PS1 mice. A, B Maximum intensity projection of a confocal image stack demonstrating aquaporin-4 immunofluorescence signal (AQP4, red) contacting capillaries labeled with a fluorescent lectin (STL, green) in representative Tg-Sham (A–C) and Tg-bTBI (D–F) mice at 3-months survival (n = 3 mice/group). Merged images (C, F) have an overlay of DAPI-labeled nuclei (blue). G Quantification of percent area coverage of sampled AQP4 immunofluorescence interfacing with the STL-labeled endothelium. N = 3 mice/group. Two-way ANOVA: F (1, 16) = 5.816, P = 0.0343. Brackets indicate differences of P < 0.05. Scale bar = 20 µm (A–F) 

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Fluids and Barriers of the CNS

ISSN: 2045-8118