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Table 1 Demographics and clinical characteristics of study participants

From: CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis

 

HC

Active

Stable

NTZ

OCZ

 

n = 20

n = 16

n = 14

n = 17

n = 14

Age, mean, SD, y

37(13)a

36(10)

43(12)

39(10)

41(11)

% Female (n)

75% (15)*

69% (11)

93%(13)*

94%(16)*

64%(9)

Clinical State

 

RRMS

RRMS

RRMS

RRMS

Disease State

 

Activeb

Stable

Stable

Stable

DD, median (IQR), mo

 

22.5(2.5–56)#

142.5(62.5–183)

87(47.5–157.5)

159.5(33–239.3)#

EDSS, median, (IQR)

 

1.5(0.3–2.4)

1.5(0.0–4.1)

1(0.0–3.0)

3.3(1.5–4.5)

  1. DD disease duration, EDSS Expanded Disability Status Scale, IQR interquartile range, m month, SD standard deviation, y year
  2. aOne undetermined value, not included in correlation analysis
  3. b14 out of 16 (87.5%) patients have confirmed contrast enhancing lesion
  4. *p < 0.002 HC vs. stable, HC vs. NTX, determined by Fishers exact test between pairs
  5. #p = 0.007 Active vs. OCZ, determined by ANOVA with Tukey's multiple comparisons test
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Fluids and Barriers of the CNS

ISSN: 2045-8118