Fig. 8
CNS-EEV correlation analysis. Correlation analysis of total EV concentrations versus total CNS-EEV concentrations of all donors (A) or when separated into different patient groups including (B) HC, active RRMS patients not receiving DMT (Active), stable RRMS patients not receiving DMT (Stable), or stable RRMS patients receiving natalizumab (NTZ) or ocrelizumab (OCZ). Note the data in C and D are identical but have been analyzed differently. Correlation analysis of total EEV levels versus total CNS-EEV levels for all donors (C) or when broken into different patient groups (D) as previously described. Note the data in C and D are identical but have been analyzed differently. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001 determined by Pearson’s r analysis. Pearson’s correlation coefficient (r) and r2 values are indicated in graphs for significant correlations