Fig. 5
From: Modeling ischemic stroke in a triculture neurovascular unit on-a-chip
Ischemic conditions cause a reduction in ATP in the neurovascular unit model. The NVU model was exposed to conditions that mimic stroke for 16 h (day 14–15 of culture) by omitting glucose, addition of antimycin-A to model hypoxia, and discontinuation of flow. a ATP concentration on blood side of NVU on-a-chip in condition with continued perfusion. b ATP concentration on brain side of NVU on-a-chip in condition with continued perfusion. c ATP concentration on blood side of NVU on-a-chip in condition with halted perfusion. d ATP concentration on brain side of NVU on-a-chip in condition with halted perfusion. Graphs show mean ± standard deviation, n = 4–5 chips. Statistical analysis was performed using Brown-Forsythe and Welch tests; *P < 0.05, **P < 0.01, ***P < 0.001