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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy

Fig. 2

Current and future in vitro BBB models. A Examples of in vitro BBB models: transwell model, microfluidic chip/membrane model, microfluidic parallel channel models, and templated model. These models utilize different engineering strategies to mimic selected aspects of the cerebrovascular microenvironment. B Towards next-generation models: to recapitulate specific biological processes occurring along the arterio-venous axis and with specificity for brain region, age, sex, ethnicity, and disease state will require more complex models that recapitulate the local microenvironment, including the spatial organization of cells, flow, blood components, etc.

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