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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Quantitative analysis of macroscopic solute transport in the murine brain

Fig. 5

Comparison of simulation to experimental DCE-MRI gadoteridol concentration data. Images of contrast concentration versus time of simulation results for a representative mouse using segmentation as described above, and optimal transport parameters (brain tissue \(D_{eff}\)  = 0.1 mm2/min, PASSurf \(D_{eff}\) = 95 mm2/min, PASBranch \(D_{eff}\) = 60 mm2/min) compared to concentration calculated from DCE-MRI signal data. The 3D images show only the elements with concentration greater than 0.1 mM and are colored by concentration according to the color bar at the figure bottom. Images are shown for the ventral surface and from a lateral view with a slight downward tilt to display details around the Circle of Willis on the ventral surface and the branching arteries. In the data images, contrast is observed moving outwards from the injection site near the cisternal aqueduct, rapidly along the ventral surface of the brain following the communicating arteries of the Circle of Willis. Contrast then moves into the brain along major branching arteries, and from these preferential routes, penetrates the wider brain tissue. Contrast present in the ventricular system has been removed from the images for direct comparison to the simulation, which modelled only glymphatic transport (not ventricular transport). In the simulations, contrast movement follows the same progression, although it does not move as rapidly towards the anterior brain at early time points and remains higher in posterior regions than in the experimental data

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