Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus

Table 2 Elevated inflammatory markers in CSF from iNPH patients

Inflammatory marker	Full name	iNPH patients	Elderly control subjects	Percent increase (%)	P-value
CCL28	C–C motif chemokine ligand 28	1.749 ± 0.222	1.495 ± 0.265	19	0.0007
CCL23	C–C motif chemokine ligand 23	3.260 ± 0.451	2.993 ± 1.013	20	0.0051
CCL3	C–C motif chemokine ligand 3	4.506 ± 0.433	4.262 ± 0.973	18	0.0056
OPG	Osteoprotegerin	10.150 ± 0.529	9.765 ± 0.478	31	0.0207
CXCL1	C-X-C motif chemokine ligand 1	6.646 ± 0.524	6.408 ± 1.091	18	0.0211
IL-18	Interleukin-18	2.639 ± 0.595	2.409 ± 1.093	17	0.0227
IL-8	Interleukin-8	8.497 ± 0.506	8.275 ± 0.787	17	0.0263
OSM	Oncostatin-M	0.726 ± 0.373	0.655 ± 0.915	5	0.0283
4E-BP1	Eukaryotic translation initiation factor 4E-binding protein 1	2.763 ± 0.653	2.544 ± 1.177	16	0.0283
CXCL6	C-X-C motif chemokine ligand 6	4.246 ± 0.637	3.929 ± 1.353	25	0.0375
Flt3L	Fms-related tyrosine kinase 3 ligand	9.100 ± 0.356	8.909 ± 0.515	14	0.0402

Data are expressed as normalized protein expression (NPX) values (mean ± SD), an arbitrary unit on log₂ scale. Percent increase represents the increase in iNPH CSF compared to CSF from elderly control subjects. Data were analyzed with an unpaired two-tailed T-test or a Mann–Whitney test. iNPH = idiopathic normal pressure hydrocephalus

ISSN: 2045-8118